Pregnancies with extreme fetal-maternal HLA incompatibility

Pregnancy requires local immune tolerization. Oocyte donation (OD) pregnancies, with extensive fetal-maternal HLA mismatching, are at higher risk of pre-eclampsia. We hypothesize that immune adaptations are needed at the fetal-maternal interface to maintain healthy pregnancy despite high HLA dissimilarity. This study is by X. Tian et al. The data sets concern raw HLA genotyping data, imaging mass cytometry data and RNA sequencing data generated from decidua basalis of fully-allogeneic healthy pregnancies, semi-allogeneic healthy pregnancies, and fully-allogeneic pregnancies with pre-eclampsia.

妊娠需建立局部免疫耐受。卵母细胞捐赠（Oocyte Donation, OD）妊娠存在广泛的胎儿-母体人类白细胞抗原（HLA）错配，其子痫前期发病风险更高。本研究假设，即便存在高度HLA错配，胎儿-母体界面仍需发生免疫适应以维持健康妊娠。本研究由X. Tian等人开展。本数据集涵盖从三类妊娠的底蜕膜中获取的原始数据：完全同种异体健康妊娠、半同种异体健康妊娠以及伴子痫前期的完全同种异体妊娠，所涉及的数据类型包括HLA基因分型原始数据、成像质谱流式细胞术数据与RNA测序数据。