Development of peptide mimics of a protective epitope of Vibrio cholerae Ogawa O-antigen and investigation of the structural basis of peptide mimicry.

This epitope is a structural peptide mimic of the Ogawa O-antigen from Vibrio cholera O1. Phage display libraries were biopanned against mAbs S-20-4 and S-20-6, which are specific for the protective epitope of Ogawa LPS, using low pH elution or non-elution. This unique sequence bound bound S-20-4.

该表位为霍乱弧菌O1血清群Ogawa型O抗原的结构肽模拟物。以针对Ogawa型脂多糖（lipopolysaccharide，LPS）保护性表位的单克隆抗体（monoclonal antibodies, mAbs）S-20-4与S-20-6为靶标，采用低pH洗脱或非洗脱策略对噬菌体展示文库进行生物淘选。该独特序列可与S-20-4特异性结合。