Multi-ancestry maternal GWAS summary statistics from "Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects"

Maternal henotypes analysed: 1-hour glucose post-OGTT (1h_Glucose), 2-hour glucose post-OGTT (2h_Glucose), fasting glucose (FG), gestational diabetes mellitus (GDM), and glycated haemoglobin (HbA1c). Quality control prior to the meta-analysis excluded SNVs with poor imputation quality (r² < 0.3 or info < 0.4), minor allele count < 10, and/or effect allele frequency < 0.1%; genetic data were lifted over to GRCh38 where required. Multi-ancestry maternal meta-analyses used MR-MEGA including three principal components; summary statistics are provided for all populations combined (FG n = 55,371; 1hG n = 38,439; 2hG n = 46,401; HbA1c n = 9,724; GDM n = 814,450 [38,305 cases]), filtered at MAF ≥ 0.01 with SNPs removed if absent from ≥ 50% of the sample. For further details on sample sizes, analytical pipelines, and cohort-specific QC procedures, see Supplementary Materials.

本研究分析的母亲表型包括：口服葡萄糖耐量试验（Oral Glucose Tolerance Test, OGTT）后1小时血糖（1h_Glucose）、OGTT后2小时血糖（2h_Glucose）、空腹血糖（fasting glucose, FG）、妊娠期糖尿病（gestational diabetes mellitus, GDM）以及糖化血红蛋白（glycated haemoglobin, HbA1c）。
荟萃分析前的质量控制步骤排除了填充质量不佳（r² < 0.3或信息得分<0.4）、次要等位基因计数<10以及/或效应等位基因频率<0.1%的单核苷酸变异（Single Nucleotide Variants, SNVs）；若有需要，将遗传数据转换至人类参考基因组GRCh38版本。
多祖先母亲队列荟萃分析采用MR-MEGA方法，并纳入3个主成分；本研究提供了所有合并人群的汇总统计量（空腹血糖[FG]：n=55,371；1小时血糖[1hG]：n=38,439；2小时血糖[2hG]：n=46,401；糖化血红蛋白[HbA1c]：n=9,724；妊娠期糖尿病[GDM]：n=814,450，其中病例数为38,305），筛选标准为次要等位基因频率（Minor Allele Frequency, MAF）≥0.01%，并移除了在≥50%的样本中未检出的单核苷酸多态性（Single Nucleotide Polymorphisms, SNPs）。
关于样本量、分析流程以及队列特异性质量控制程序的更多细节，请参见补充材料。