Developing High-Affinity Decoy Receptor Optimized for Multiple Myeloma and Diffuse Large B Cell Lymphoma Treatment [Ribo-seq]

This study demonstrates the dichotomous activities of APRIL and BAFF in MM and DLBCL, which can be safely targeted by an engineered fusion protein designed to trap both ligands with ultrahigh binding affinity. Comparative ribosome and gene expression profiling analysis of RNA-seq data for U266 multiple myeloma cells and its knockdown derivatives (siBCMA).

本研究揭示了增殖诱导配体（APRIL）与B细胞活化因子（BAFF）在多发性骨髓瘤（MM）和弥漫性大B细胞淋巴瘤（DLBCL）中的双向活性，该两类配体可通过一种经设计以超高结合亲和力捕获它们的工程化融合蛋白实现安全靶向。本研究针对U266多发性骨髓瘤细胞及其BCMA敲低衍生细胞株（siBCMA）的RNA测序（RNA-seq）数据开展了核糖体与基因表达谱对比分析。