Proteomic of Chaihu-Shugan-San (CSS), Rou Gan, and Shu Gan treat chronic unpredictable mild stress (CUMS) rat with Tandem Mass Tags

Chaihu-Shugan-San (CSS) is a classical prescription used to treat depression. According to the traditional Chinese medicine (TCM) principle, the 2 decomposed recipes in CSS exert synergistic effects, including Shu Gan (stagnated Gan-Qi dispersion) and Rou Gan (pain alleviation). However, the specific mechanism and compatibility rule remain to be explored. We aimed to analyze the advantage of TCM compatibility in CSS prescriptions and explore its anti-depression mechanisms.

柴胡疏肝散（Chaihu-Shugan-San, CSS）是一款用于治疗抑郁症的经典方剂。依据中医（Traditional Chinese Medicine, TCM）理论，该方剂所含的两个拆方可发挥协同效应，分别为疏肝（散郁滞肝气）与柔肝（止痛）。然而，其具体作用机制与配伍规律仍有待进一步探究。本研究旨在剖析柴胡疏肝散的中医药配伍优势，并探索其抗抑郁的作用机制。