Locked 468-gene panel and methods for within-disease transcriptomic meta-analyses of AD, ASD, PD, MS, and ALS

Version 1.3 (September 2026). Adds AD_meta_reproduction_package.zip: per-cohort input tables and scripts that reproduce the Alzheimer's disease six-cohort meta-analysis (458 analyzable / 167 FDR-significant / 141 high-confidence genes) gene by gene, together with the sensitivity analyses reported in the revised Alzheimer's disease manuscript (Table S4). The 468-gene panel, the exclusion list, the high-confidence rule and the locked counts are unchanged. Version 1.2 (September 2026). Adds the Parkinson disease per-gene meta-analysis table (419 analyzable genes, 91 FDR-significant, 56 high-confidence) as a standalone workbook and CSV with the locked cohort contrast definitions; the table is identical to the PD sheet of CONSOLIDATED_468_FINAL_7.6.26.xlsx in version 1.1. Adds definitions_locked.csv (status FINAL) and a README that corrects two statements in the version 1.1 README: 10.5281/zenodo.22178094 is the record DOI of version 1.0, not the concept DOI (the all-versions DOI is 10.5281/zenodo.22178093), and the disease-resolved companion papers are posted at Research Square, not SSRN, with the methods-and-panel manuscript under review at Molecular Neurobiology. The 468-gene panel, the 22-symbol exclusion list, the high-confidence rule, the locked counts, and the pipeline are unchanged from version 1.0. ORCID iD: 0000-0003-2059-622X