The Association Between Neurologic Pupillary Index (NPi) and Functional Outcomes in Critically Ill Children

The neurologic pupillary index (NPi) is an objective measurement of pupillary reactivity which may play a role in prognostication after critical illness. We hypothesized the minimum measured NPi in critically ill children would correlate with unfavorable outcomes (UO) at hospital discharge. In this single-center retrospective observational cohort study, the minimum NPi (NPimin) was compared with outcome. Unfavorable outcome was defined by death or a change in functional status scale (FSS) score of > 3 points from baseline to hospital discharge. Additionally, UO was further sub-classified into categories of severe disability (SD), defined as total discharge composite FSS of > 16 points or death and no severe disability (NSO), survivors with discharge FSS

神经瞳孔指数（neurologic pupillary index, NPi）是量化瞳孔反应性的客观测量指标，在重症疾病后的预后评估中具备潜在应用价值。我们提出研究假设：重症儿童患者测得的最低神经瞳孔指数与出院时的不良预后（unfavorable outcomes, UO）存在相关性。本项单中心回顾性观察队列研究对最低神经瞳孔指数（NPi_min）与临床结局展开了对比分析。不良预后被定义为死亡，或从基线至出院时功能状态量表（functional status scale, FSS）评分较基线变化幅度＞3分。此外，本研究进一步将不良预后细分为重度残疾（severe disability, SD，定义为出院时综合功能状态量表评分＞16分）、死亡以及非重度残疾（no severe disability, NSO，即出院时存活且具备功能状态量表评分的幸存者）