Evaluation of adjuvant chemotherapy in feline injection site-associated sarcoma

ABSTRACT Feline Injection Site-Associated Sarcoma (FISS) is a neoplasm that implies in reduction of quality of life and overall survival in feline patients. A retrospective study of 13 cases of FISS was conducted to evaluate the efficacy of surgical treatment associated to chemotherapy with doxorubicin or carboplatin. Local recurrence occurred in all patients. Patients treated with surgery and chemotherapy presented a longer overall survival and disease-free interval when compared to those that solely received surgical treatment, although no statistical significance was observed (p= 0.3360 and 0.7506, respectively). Surgery remains as the main option for FISS treatment. Further prospective studies with larger samples are warranted to investigate the benefit of chemotherapy for this neoplasm.

摘要：猫注射部位相关肉瘤（Feline Injection Site-Associated Sarcoma, FISS）是一类会降低患猫生活质量并缩短其总生存期的肿瘤。本研究纳入13例猫注射部位相关肉瘤病例，开展回顾性研究以评估多柔比星或卡铂化疗联合手术治疗的疗效。结果显示，所有受试患猫均出现局部复发。与仅接受手术治疗的患猫相比，接受手术联合化疗的患猫总生存期与无病间期更长，但差异未达到统计学显著性（分别为p=0.3360和0.7506）。手术仍是猫注射部位相关肉瘤治疗的主要手段。未来需开展更大样本量的前瞻性研究，以探讨该肿瘤化疗的获益价值。