Construction of the Adamantane Core of Plukenetione-Type Polycyclic Polyprenylated Acylphloroglucinols

The construction of a highly functionalized adamantane core of plukenetione-type polycyclic polyprenylated acylphloroglucinols (PPAPs) is described. The method features the construction of the bicyclo[3.3.1]nonane core (3) by successive Michael reactions and the construction of the adamantane core of plukenetione-type PPAPs by acid-catalyzed cyclization of a bicyclo[3.3.1]nonane precursor (2).

本研究报道了蒲桃酮型多环多异戊烯基间苯三酚类化合物（plukenetione-type polycyclic polyprenylated acylphloroglucinols，PPAPs）的高官能化金刚烷母核的构建方法。该方法通过连续迈克尔加成反应构建双环[3.3.1]壬烷母核（3），并通过双环[3.3.1]壬烷前体（2）的酸催化环化反应，完成蒲桃酮型PPAPs的金刚烷母核构建。