Effects of respiratory muscle training on parasympathetic activity in diabetes mellitus

This study verified the effects of respiratory muscle training (RMT) on hemodynamics, heart rate (HR) variability, and muscle morphology in rats with streptozotocin-induced diabetes mellitus (DM). Thirty-six male Wistar rats were randomized into 4 groups and 34 completed the study: i) sham-sedentary (Sham-ST; n=9); ii) sham-RMT (Sham-RMT; n=9); iii) DM-sedentary (DM-ST; n=8); and iv) DM-RMT (DM-RMT; n=8). Hemodynamics were assessed by central cannulation, and R-R intervals were measured by electrocardiogram. In addition, the effects of RMT on the cross-sectional area of the diaphragm, anterior tibial, and soleus muscles were analyzed. The induction of DM by streptozotocin resulted in weight loss, hyperglycemia, reduced blood pressure, and attenuated left ventricular contraction and relaxation (P

本研究验证了呼吸肌训练（respiratory muscle training, RMT）对链脲佐菌素诱导的糖尿病（diabetes mellitus, DM）大鼠血流动力学、心率（heart rate, HR）变异性以及肌肉形态的影响。将36只雄性Wistar大鼠随机分为4组，最终34只完成全部实验：①假手术久坐组（Sham-ST；n=9）；②假手术呼吸肌训练组（Sham-RMT；n=9）；③糖尿病久坐组（DM-ST；n=8）；④糖尿病呼吸肌训练组（DM-RMT；n=8）。采用中心插管法评估血流动力学，并通过心电图测量R-R间期。此外，本研究还分析了呼吸肌训练对膈肌、胫骨前肌以及比目鱼肌横截面积的影响。链脲佐菌素诱导的糖尿病造模可导致大鼠体重下降、高血糖、血压降低，并减弱左心室收缩与舒张功能（P