Cell-free DNA sequencing of pregnant women

Circulating nucleic acids in plasma provide a window to the molecules released throughout the human body. This project collected cfDNA from pregnant women throughout their pregnancies, in order to observe the fraction of fetal DNA as well as looking at the non-human sequences (i.e. bacterial and viral), especially those parts that are novel (i.e. biological dark matter).

血浆中的循环核酸（circulating nucleic acids）为探究释放至全身的人体分子提供了独特的研究视角。本项目从妊娠全程的孕妇体内采集循环游离DNA（cell-free DNA，cfDNA），旨在检测胎儿DNA的占比，同时分析其中的非人类序列（即细菌与病毒序列），尤其是其中的新型序列（即生物暗物质）。