Analysis of potential drug interactions in medical clinic sector in a Hospital of João Pessoa - PB

Abstract The objective of this study was to evaluate drug interactions based on medical records of patients hospitalized in University Hospital Lauro Wanderley (UHLW) in João Pessoa-PB, Brazil. This was a quantitative, descriptive study with a cross-sectional design. This research was conducted in the medical clinic of the above hospital by analyzing pharmaceutical intervention in medical records. The investigated samples consisted of all medical profiles with drug interaction information of patients hospitalized from June 2016 to June 2017. Most of these drug interactions were determined and classified by Micromedex® Solutions database. This research was approved by the Ethics Committee in Institutional Human Research, protocol number 2.460.206. In total, 331 drug interactions were found in 131 medical profiles. Dipyrone, enoxaparin, sertraline, ondansetron, quetiapine, tramadol, bromopride, amitriptyline, and simvastatin were medications that showed highest interactions. According to Anatomical Therapy Classification (ATC), drugs that act on the central nervous system result in more interactions. The most prevalent interaction was between dipyrone and enoxaparin. Some limitations of this study are the lack of notifications and data on drug interactions.

摘要 本研究旨在基于巴西帕拉伊巴州若昂佩索阿市劳罗·万德利大学医院（University Hospital Lauro Wanderley, UHLW）的住院患者医疗记录，评估药物相互作用情况。本研究为采用横断面设计的定量描述性研究。本研究通过分析该院内科临床科室医疗记录中的药物干预情况开展。研究样本为2016年6月至2017年6月期间住院患者的全部含药物相互作用信息的医疗档案。其中大部分药物相互作用通过Micromedex® Solutions数据库完成判定与分类。本研究已通过机构人类研究伦理委员会审查，审批编号为2.460.206。最终在131份医疗档案中共检出331例药物相互作用。安乃近（Dipyrone）、依诺肝素（enoxaparin）、舍曲林（sertraline）、昂丹司琼（ondansetron）、喹硫平（quetiapine）、曲马多（tramadol）、溴必利（bromopride）、阿米替林（amitriptyline）与辛伐他汀（simvastatin）为发生药物相互作用频次最高的药物。依据解剖治疗分类系统（Anatomical Therapy Classification, ATC），作用于中枢神经系统的药物引发的药物相互作用最为多见。最为常见的药物相互作用为安乃近与依诺肝素之间的相互作用。本研究存在一定局限性，即缺乏药物相互作用的相关上报信息与数据记录。