Bone Fractures in Adolescent Master Protocol, PH200

Bone fractures (July 2024). Data updated in 2024 in DASH to include the follow-up time points through the final participant visit in 2020.
Study Description
The PHACS AMP study is designed to define the impact of HIV infection and antiretroviral therapy on pre-adolescents and adolescents with perinatal HIV infection. Domains investigated include growth and sexual maturation; metabolic risk factors for cardiovascular disease; cardiac function; bone health; neurologic, neurodevelopment, language, hearing, and behavioral function; and adolescent gynecology and HPV infection. Biospecimens are available. AMP includes 451 perinatally HIV-infected (PHIV) youth and 227 perinatally HIV-exposed uninfected (PHEU) youth, age 6 to 17 years at study entry. [587 caregivers also enrolled to provide information on their children.]

骨折数据集（2024年7月）已于2024年在DASH平台完成更新，补充了截至2020年所有受试者末次随访的全部随访时间节点数据。

研究概况
PHACS AMP研究旨在明确人类免疫缺陷病毒（HIV，Human Immunodeficiency Virus）感染与抗反转录病毒治疗（antiretroviral therapy）对围生期HIV感染（perinatal HIV infection）青春期前儿童及青少年的影响。本研究涵盖的研究领域包括生长发育与性成熟、心血管疾病代谢危险因素、心脏功能、骨骼健康、神经及神经发育、语言、听力与行为功能，以及青春期妇科与HPV（Human Papillomavirus）感染。本研究可提供生物样本。
本研究共纳入451名围生期HIV感染（perinatally HIV-infected, PHIV）青少年及227名围生期HIV暴露但未感染（perinatally HIV-exposed uninfected, PHEU）青少年，入组时年龄为6至17岁。另有587名儿童照料者入组，以提供其子女的相关研究信息。