PTM-MS of MEKi treated sgNF1 iPN cells

The goal of the study was to profile the effects of MEK inhibition in iPN cells or control sgNTC iPN cells. Phosphoproteomics was performed to profile global changes in phosphorylation after treatment with selumetinib.

本研究旨在分析MEK抑制（MEK inhibition）对iPN细胞，以及转染非靶向向导RNA对照（sgNTC）的iPN细胞的影响。本研究采用磷酸化蛋白质组学（phosphoproteomics）技术，解析经司美替尼（selumetinib）处理后细胞内磷酸化修饰的全局变化情况。