Whole genome transcriptomic analysis of T. onnuriuens NA1 wild-type and MC11 mutant strains on CO

Previously, we reported that the TON_1525 (T55I) (designated as MC11) strain showed superior activity in CO oxidation than the wild-type strain. To understand the in vivo role of TON_1525 in this strain on CO-supplemented medium, transcriptome changes were investigated. The expression profiles of genes in wild-type and MC11 mutant strains under CO-supplemented conditions were measured.

此前我们已有报道，TON_1525 (T55I)（命名为MC11）菌株在一氧化碳（CO）氧化过程中的活性优于野生型菌株。为探明该菌株中TON_1525在添加一氧化碳的培养基中的体内功能，我们对转录组变化进行了研究。我们测定了野生型菌株与MC11突变菌株在添加一氧化碳的培养条件下的基因表达谱。