From lipids to lymphocytes: research on the role of lipidomics and immune checkpoints in primary glomerulopathies

The research data is related to the project "From lipids to lymphocytes: research on the role of lipidomics and checkpoints in primary glomerulopathies," funded by National Science Centre (Poland) under the MINIATURA 8 call (no. 2024/08/X/NZ5/00659).The dataset contains plasma lipid profile results from patients and control subjects obtained using LC-MS/MS. It includes panels for acylcarnitines, cholesterol esters, di- and triacylglycerols, and glycerophospholipids (including lysophosphatidylcholine and phosphatidylcholine, including ether forms). Each result is accompanied by a quality status (e.g., Valid, ULOQ).The data are organized in a "one sample = one row" format, with fields identifying the sample and group. The dataset is designed for comparative analyses, biomarker discovery, and integration with immunological data in primary glomerulopathies.Method Information: Assays were performed using the AbsoluteIDQ® p400 HR kit (Biocrates Life Sciences AG, Innsbruck, Austria). Signal acquisition and analysis details were standardized for all samples, enabling comparability of results between cohorts.Legend: abbreviations and notation for the lipidomics datasetID – sample identifier; AC – acylcarnitines; CE – cholesterol esters; DG – diacylglycerols; TG – triacylglycerols; LPC – lysophosphatidylcholine; PC – phosphatidylcholine; PC-O – ether-linked PC (plasmalogens); DG-O – ether-linked DG; Hexose – sum of hexoses; notation (x:y) – number of carbon atoms:number of double bonds; _status – QC status column: Valid – reliable (quantitative) result; ULOQ – above upper limit of quantification; n/a – not available;

本研究数据关联由波兰国家科学中心（National Science Centre (Poland)）依据MINIATURA 8计划资助的项目"From lipids to lymphocytes: research on the role of lipidomics and checkpoints in primary glomerulopathies"（即《从脂质到淋巴细胞：原发性肾小球病中脂质组学与免疫检查点的作用研究》），项目编号为2024/08/X/NZ5/00659。本数据集包含采用液相色谱-串联质谱法（LC-MS/MS）获取的原发性肾小球病患者与健康对照个体的血浆脂质谱检测结果，其检测组分涵盖酰基肉碱（acylcarnitines）、胆固醇酯（cholesterol esters）、二酰甘油、三酰甘油以及甘油磷脂（glycerophospholipids），其中包括溶血磷脂酰胆碱（lysophosphatidylcholine）与磷脂酰胆碱（phosphatidylcholine），且涵盖醚键连接型脂质。每一项检测结果均附带质量状态标识（例如Valid、ULOQ）。数据采用"单样本=单行"格式进行组织，包含用于标识样本与分组的字段。本数据集旨在用于原发性肾小球病的比较分析、生物标志物发现，以及与免疫学数据的整合研究。方法学说明：本检测采用AbsoluteIDQ® p400 HR试剂盒（奥地利因斯布鲁克Biocrates生命科学公司（Biocrates Life Sciences AG））完成。所有样本的信号采集与分析流程均经过标准化处理，确保不同队列间的检测结果具有可比性。术语说明：脂质组学数据集的缩写与标注规则如下：ID：样本标识符；AC：酰基肉碱；CE：胆固醇酯；DG：二酰甘油；TG：三酰甘油；LPC：溶血磷脂酰胆碱；PC：磷脂酰胆碱；PC-O：醚键连接型磷脂酰胆碱（缩醛磷脂，plasmalogens）；DG-O：醚键连接型二酰甘油；Hexose：己糖总含量；标注(x:y)：碳原子数:双键数；_status：质量控制状态列：Valid表示结果可靠（可定量）；ULOQ表示结果超出定量上限；n/a表示无有效数据。