DMAP based habitat-specific metagenomic gene catalogs, http://www.cbrc.kaust.edu.sa/dmap. Habitat-specific Metagenomic Gene Catalogs

Samples from several public ENA shotgun metagenomic studies were collected and assembled to predict full length genes. Gene from each habitat were clustered to produce a non-redundant gene catalog. Gene catalogs were annotated for taxonomic and extended gene function information (KO, GO, InterPro, Enzyme, eggNOG, Pathways, Industrial Proteins, Bioactive genes) using Annotation module of Dragon Metagenomic Analysis Platform (DMAP) as Gene Information Tables (GITs). These GITs are useful for data exchange and analysis across different metagenomic analysis platforms and also machine learning or Artificial Intelligence towards monitoring different ecological or host specific environments. To enable access for larger scientific community in order to search, browse or compare samples and gene catalogs, these GITs are indexed using Solr Lucene and are available through http://www.cbrc.kaust.edu.sa/dmap

本研究收集了多项公开欧洲核苷酸档案馆（European Nucleotide Archive, ENA）的鸟枪法宏基因组学研究样本，并进行组装以预测全长基因。随后对不同生境来源的基因进行聚类，构建得到非冗余基因集。使用龙形宏基因组分析平台（Dragon Metagenomic Analysis Platform, DMAP）的注释模块，对该基因集开展分类学与扩展基因功能信息注释，涵盖KO、GO、InterPro、Enzyme、eggNOG、Pathways、Industrial Proteins、Bioactive genes等类别，并生成基因信息表（Gene Information Tables, GITs）。此类基因信息表可支持不同宏基因组分析平台间的数据交换与分析，同时也可应用于机器学习或人工智能（Artificial Intelligence, AI）相关研究，用于监测不同生态环境或宿主特异性环境。为便于更广泛的科研群体检索、浏览或比对样本与基因集，本研究通过Solr Lucene对这些基因信息表进行索引，并提供访问接口：http://www.cbrc.kaust.edu.sa/dmap