Table_1_Association between triglyceride glucose index and breast cancer in 142,184 Chinese adults: findings from the REACTION study.docx

BackgroundThe triglyceride glucose (TyG) index has been associated with an increased risk in breast cancer. However, this association remains unclear among the Chinese population. This study aimed to investigate whether the TyG index is associated with the risk of prevalent breast cancer in Chinese women.
MethodsThis cross-sectional study included 142,184 women from the REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal) Study, which recruited adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012. The TyG index was calculated according to the formula: Ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). Multivariable-adjusted logistic regression models were used to evaluate odds ratios (ORs) and 95% confidence intervals (CIs) regarding the associations between the TyG index and breast cancer.
ResultsMultivariable-adjusted logistic regression analysis showed that compared with the lowest quartile of the TyG index, the highest quartile of the TyG index was significantly associated with an increased risk of prevalent breast cancer, with an OR (95% CI) of 1.61 (1.19–2.17). In the stratified analysis, the association of each 1 SD increase in the TyG index with risk of prevalent breast cancer was more dominant in individuals with menarche at age 13–17, those who were postmenopausal, those with a history of breastfeeding, and those who had two to four children, with the ORs (95% CIs) of 1.35 (1.09–1.68), 1.27 (1.05–1.54), 1.26 (1.05–1.52), and 1.32 (1.08–1.62), respectively. Moreover, among those without discernible insulin resistance (homeostatic model assessment-insulin resistance [HOMA-IR] ≥2.5), hyperglycemia and dyslipidemia, each 1 SD increase in the TyG index was associated with a 1.36-fold increase in breast cancer risk, with an OR (95% CI) of 2.36 (1.44–3.87).
ConclusionThe TyG index is significantly associated with the prevalent breast cancer risk among middle-aged and elderly Chinese women.

Background
甘油三酯葡萄糖（TyG）指数与乳腺癌风险升高相关，但该关联在中国人群中仍不明确。本研究旨在探讨TyG指数与中国女性现患乳腺癌风险的相关性。
Methods
本项横断面研究纳入来自中国糖尿病患者癌症风险纵向评估（REACTION）研究的142184名女性受试者。该研究于2011至2012年间，从中国内地25个研究中心招募了40岁及以上的成年受试者。TyG指数按照以下公式计算：Ln（空腹甘油三酯[mg/dL] × 空腹血糖[mg/dL]/2）。采用多因素校正logistic回归模型评估TyG指数与乳腺癌关联的比值比（OR）及95%置信区间（CI）。
Results
多因素校正logistic回归分析显示，与TyG指数最低四分位数组相比，最高四分位数组的现患乳腺癌风险显著升高，OR（95%CI）为1.61（1.19~2.17）。分层分析结果显示，TyG指数每升高1个标准差，现患乳腺癌风险在月经初潮年龄为13~17岁、绝经后、有母乳喂养史及生育2~4个子女的人群中更为显著，对应的OR（95%CI）分别为1.35（1.09~1.68）、1.27（1.05~1.54）、1.26（1.05~1.52）及1.32（1.08~1.62）。此外，在无明确胰岛素抵抗（稳态模型评估-胰岛素抵抗[HOMA-IR]≥2.5）、高血糖及血脂异常的人群中，TyG指数每升高1个标准差，乳腺癌风险升高1.36倍，OR（95%CI）为2.36（1.44~3.87）。
Conclusion
TyG指数与中国中老年女性的现患乳腺癌风险显著相关。