Treatment strategies for chronic hepatitis B based on covalently closed circular DNA dynamics

Cure of chronic hepatitis B virus （HBV） infection is the ultimate goal in HBV-related research， and exploring potential curative pathways may help to identify key research directions. Covalently closed circular DNA （cccDNA）， as the most difficult genetic material to be eliminated within the HBV replication cycle， is not only a primary impediment to achieving cure， but also a key issue for establishing an analytical framework for cure strategies. This article reviews the thinking framework of “cccDNA dynamics”， further elaborates on its core implications， and systematically discusses the main strategies to promote cccDNA decay.

慢性乙型肝炎病毒（hepatitis B virus, HBV）感染的治愈是HBV相关研究的终极目标，探索潜在治愈途径有助于明确关键研究方向。共价闭合环状DNA（covalently closed circular DNA, cccDNA）作为HBV复制周期中最难被清除的遗传物质，不仅是实现治愈的主要障碍，也是构建治愈策略分析框架的核心问题。本文综述了“cccDNA动态学”的思维框架，进一步阐述了其核心内涵，并系统探讨了促进cccDNA降解的主要策略。