High-confidence mitochondrial read alignments of liver cancer samples in four mouse species

This BioProject contains the BAM files with the mitochondrial reads used in Daunesse et al. 2025 for heteroplasmy detection across four mouse strains: Mus musculus domesticus (C57BL/6J), Mus musculus castaneus (CAST/EiJ), Mus musculus musculus (C3H/HeJ), and Mus caroli (CAROLI/EiJ) in liver cancer samples. The dataset includes both standard and shift-mapped alignments. The shift-mapping approach repositions the linear start of the mitochondrial genome by 8,150 bp to improve read alignment at artificial breakpoints, reducing coverage biases.

本生物项目（BioProject）包含Daunesse等人2025年的研究中，用于肝癌样本中4种小鼠品系异质性检测（heteroplasmy detection）的线粒体读段（mitochondrial reads）对应的BAM文件（BAM）。这4个小鼠品系分别为：小家鼠家栖亚种（Mus musculus domesticus，C57BL/6J）、小家鼠卡斯蒂利亚亚种（Mus musculus castaneus，CAST/EiJ）、小家鼠指名亚种（Mus musculus musculus，C3H/HeJ）以及卡氏小家鼠（Mus caroli，CAROLI/EiJ）。本数据集包含标准比对与位移映射比对两种结果。位移映射方法通过将线粒体基因组的线性起始位点偏移8150个碱基对，可改善人工断点处的读段比对效果，降低覆盖度偏差。