Physicochemical Descriptors of Aromatic Character and Their Use in Drug Discovery

Published physicochemical descriptors of molecules that convey aromaticity-related character are reviewed in the context of drug design and discovery. Studies that have employed aromatic descriptors are discussed, and several descriptors are compared and contrasted.本文结合药物设计与发现的研究背景，综述了已发表的、用于表征分子芳香性相关特征的物理化学描述符（physicochemical descriptors）。随后，本文讨论了采用芳香性描述符的相关研究，并对若干描述符进行了对比分析。