FInnish National Protein Crystallography Consortium

The Finnish BAG encompasses 25 groups active in crystallography in Finland. The projects vary widely and include membrane proteins such as membrane pyrophosphatases, and various protein complexes and receptors (growth factor receptors, integrins), signaling proteins such as kinases, other proteins involved in disease and antibiotics development (neuronal adhesion and myelin proteins, PP2A, ADP-ribosylation and biocatalytic enzymes) and several pathogen proteins (e.g. viral proteins) and various enzyme targets and e.g. studies on phytochrome photoreceptors and complexes involved in actin and cytoskeleton dynamics and regulation. Overall the BAG serves the national needs for highly variable projects, with different biological and biotechnological applications. Several project will benefit from microfocus beam lines and tunable wavelength options for phasing, others benefit from quick robust screening by MASSIF. Biology lab is needed for SAXS experiments.

芬兰BAG涵盖芬兰国内25个从事晶体学研究的团队。这些项目范围广泛，包括膜焦磷酸酶等膜蛋白、各类蛋白复合物与受体（生长因子受体、整合素）、激酶等信号蛋白、参与疾病与抗生素研发的其他蛋白（神经黏附与髓鞘蛋白、PP2A、ADP核糖基化（ADP-ribosylation）及生物催化酶），以及多种病原体蛋白（如病毒蛋白）、各类酶靶点，还有植物光敏色素受体研究、参与肌动蛋白及细胞骨架动态与调控的复合物研究等。总体而言，BAG满足了芬兰国内对高度多样化项目的需求，这些项目具有不同的生物与生物技术应用场景。部分项目将受益于用于相位测定的微聚焦光束线和可调波长选项，其他项目则可通过MASSIF实现快速稳健的筛选。小角X射线散射（SAXS）实验需要生物实验室支持。