MIchigan-CORnell-TEXas (MICORTEX) - Estimating the Contribution of the Network of DNA Sequence Variations to the Prediction of CHD and Diabetes

This sub-study [phs000860](./study.cgi?study_id=phs000860) MICORTEX contains genotype and selected phenotype of subjects available from the [phs000860](./study.cgi?study_id=phs000860) study. Summary level phenotypes for the NHLBI ARIC Cohort study participants can be viewed at the top-level study page [phs000280](./study.cgi?study_id=phs000280) ARIC Cohort. Individual level phenotype data and molecular data for all ARIC Cohort top-level study and sub-study are available by requesting Authorized Access to the NHLBI ARIC Cohort [phs000280](./study.cgi?study_id=phs000280) study.

MICORTEX is a program in systems biology, funded by the National Institute of General Medical Sciences (NIGMS), which focuses on developing resources and non-traditional analytical approaches for answering the primary questions faced by investigators seeking to characterize the impact of DNA sequence variation on human health: Which DNA sequence variations, in which individuals, in which populations and in which environmental contexts within a particular population, predict incidence of coronary heart disease (CHD) and diabetes beyond established risk factors?

本子研究**MICORTEX**（对应编号[phs000860](./study.cgi?study_id=phs000860)）包含源自母研究[phs000860](./study.cgi?study_id=phs000860)的受试者基因型（genotype）与选定表型（phenotype）数据。美国国家心肺血液研究所（National Heart, Lung, and Blood Institute, NHLBI）ARIC队列参与者的汇总级表型数据，可在其顶级研究页面[phs000280](./study.cgi?study_id=phs000280)的ARIC队列板块查看。所有ARIC队列顶级研究及各子研究的个体级表型数据与分子数据，需通过申请获取美国国家心肺血液研究所ARIC队列研究[phs000280](./study.cgi?study_id=phs000280)的授权访问权限后方可获取。
MICORTEX是由美国国家普通医学科学研究所（National Institute of General Medical Sciences, NIGMS）资助的系统生物学项目，其聚焦于开发相关资源与非传统分析方法，以解答研究者在探索DNA序列变异对人类健康的影响时所面临的核心问题：在既定风险因素之外，哪些DNA序列变异、在哪些个体、哪些人群以及特定人群内的哪些环境背景下，能够预测冠心病（coronary heart disease, CHD）与糖尿病的发病风险？