A targetable CD109-Janus kinase-Stat axis in metastatic lung cancer.

By coupling the systematic genomic analysis of purified cancer cells in distinct malignant states from mouse models with extensive human validation, we uncovered several key regulators of metastatic ability, including an actionable pro-metastatic CD109--Jak--Stat3 axis.

本研究通过将小鼠模型中不同恶性状态下纯化癌细胞的系统性基因组分析，与大规模人类样本验证相结合，成功揭示了若干调控肿瘤转移能力的关键调控因子，其中包含一条可靶向干预的促转移分化簇109（CD109）-Janus激酶（Jak）-信号转导与转录激活因子3（Stat3）信号轴。