Additional file 1 of Causal relationship between gut microbiota and tuberculosis: a bidirectional two-sample Mendelian randomization analysis

Additional file 1: Table S1. STROBE-MR Checklist. Table S2. Excluded single-nucleotide polymorphisms of potential confounders. Table S3. Single-nucleotide polymorphisms used as instrumental variables for TB in the UK Biobank database in MR analysis. Table S4. Single-nucleotide polymorphisms used as instrumental variables for TB in the FinnGen database in MR analysis. Table S5. Full results of MR estimates for the association between gut microbiota and TB in the UK Biobank database. Table S6. Full results of MR estimates for the association between gut microbiota and TB in the FinnGen database. Table S7. Full results of MR estimates for the association between gut microbiota and RTB in the FinnGen database. Table S8. Full results of MR estimates for the association between gut microbiota and EPTB in the FinnGen database. Table S9. Single-nucleotide polymorphisms used as instrumental variables for gut microbiota at the threshold of P < 1e−5 in reverse MR analysis. Table S10. MR results of causal links between TB on gut microbiota at the threshold of P < 1e−5 in the reverse MR analysis. Table S11. Results of MR Steiger direction test. Table S12. Results of sensitivity analyses between gut microbiota and TB with IVW P < 0.05. Table S13. Results of sensitivity analysEs between TB and gut microbiota in the reverse MR analysis.

附加文件1：表S1。STROBE-MR 检查表（STROBE-MR Checklist）。表S2：潜在混杂因素的排除单核苷酸多态性（single-nucleotide polymorphisms）。表S3：孟德尔随机化（Mendelian Randomization，MR）分析中，英国生物库（UK Biobank）数据库内用作结核病（tuberculosis，TB）工具变量的单核苷酸多态性。表S4：孟德尔随机化分析中，芬兰基因研究项目（FinnGen）数据库内用作结核病工具变量的单核苷酸多态性。表S5：英国生物库数据库内肠道菌群与结核病关联的孟德尔随机化估计结果完整汇总。表S6：芬兰基因研究项目数据库内肠道菌群与结核病关联的孟德尔随机化估计结果完整汇总。表S7：芬兰基因研究项目数据库内肠道菌群与复发性结核病（recurrent TB，RTB）关联的孟德尔随机化估计结果完整汇总。表S8：芬兰基因研究项目数据库内肠道菌群与肺外结核病（extrapulmonary TB，EPTB）关联的孟德尔随机化估计结果完整汇总。表S9：反向孟德尔随机化分析中，以P < 1e−5为阈值、用作肠道菌群工具变量的单核苷酸多态性。表S10：反向孟德尔随机化分析中，以P < 1e−5为阈值的结核病对肠道菌群因果关联的孟德尔随机化结果。表S11：MR Steiger方向检验结果。表S12：以逆方差加权（Inverse Variance Weighted，IVW）法P < 0.05为阈值的肠道菌群与结核病关联的敏感性分析结果。表S13：反向孟德尔随机化分析中结核病与肠道菌群关联的敏感性分析结果。