Data_Sheet_1_Correlation between temporal muscle thickness and grip strength in hemiplegic patients with acute stroke.PDF

Recently, temporal muscle thickness (TMT) has been investigated as a novel surrogate marker for muscle mass and function in neurologic patients. This study aimed to assess the correlation of TMT with grip strength to establish a new parameter for predicting pre-stroke sarcopenia. A total of 358 patients who were newly diagnosed with acute ischemic stroke at our institution between November 2021 and August 2022 were enrolled. Eighty-four patients met the eligibility criteria. The mean TMT was measured within initial brain MRI using previously described methods. Pearson's correlation analyses assessed the relationship between grip strength and TMT. Multiple logistic regression analyses were performed to identify associations between TMT and other associated factors including grip strength, sarcopenia risk, body mass index, age, Charlson Comorbidity Index and Geriatric nutrition risk index. Mean TMT values indicated a strong correlation with the grip strength of the non-hemiplegic hand in both male and female patients. Multiple logistic regression analyses showed that TMT was associated with grip strength and sarcopenia risk in hemiplegic patients. Measuring TMT using cranial MR images during the initial stages of stroke could help predict a patient's pre-stroke muscle strength status. Further studies are required to apply TMT in pre-stroke sarcopenia diagnosis.

颞肌厚度（temporal muscle thickness, TMT）近年来被研究作为神经科患者肌肉质量与功能的新型替代标志物。本研究旨在评估颞肌厚度与握力的相关性，以建立用于预测卒中前肌少症的新型参数。本研究于2021年11月至2022年8月期间，纳入我院新确诊为急性缺血性卒中的患者共358例，最终84例符合入组标准。采用既往报道的方法，通过初始颅脑MRI测量平均颞肌厚度。采用Pearson相关分析评估握力与颞肌厚度的相关性。通过多重logistic回归分析，探究颞肌厚度与握力、肌少症风险、体质量指数、年龄、查尔森合并症指数（Charlson Comorbidity Index）及老年营养风险指数（Geriatric nutrition risk index）等相关因素的关联。无论男性还是女性患者，平均颞肌厚度值均与非偏瘫侧手部握力呈显著强相关。多重logistic回归分析结果显示，偏瘫患者的颞肌厚度与握力及肌少症风险存在关联。在卒中急性期通过颅脑MRI测量颞肌厚度，有助于预测患者卒中前的肌肉力量状态。未来仍需开展进一步研究，以将颞肌厚度应用于卒中前肌少症的临床诊断中。