Role of ADAR1 on transcriptional output in cancer cells

The loss of ADAR1 significantly reduced ribosome production, decreased tumor translational efficiency, and impaired the translation of oncogenic pathways. RNA-Seq was performed in ADAR1-overexpressing and control MDA-MB-231 xenografts, with or without CX-5461 treatment.

腺苷脱氨酶作用于RNA 1（ADAR1）的缺失会显著降低核糖体生成，减弱肿瘤翻译效率，并损伤致癌通路的翻译过程。本研究对过表达ADAR1的MDA-MB-231异种移植瘤及对照MDA-MB-231异种移植瘤，分别施加CX-5461处理或不予处理，并开展RNA测序（RNA-Seq）分析。