The self-renewal function of Oct-4 can be replaced by the EWS-OCT-4 fusion protein in embryonic stem cells

EWS-Oct-4 can effectively replace Oct-4, which has significant implications for advancements in stem cell research and regenerative medicine Overall design: we used J1 ESC cell line as control group, and EWS-OCT4, OCT4 stable cell line as an experimental group. All experiments are triplicated.

EWS-Oct-4可有效替代Oct-4，该成果对干细胞研究与再生医学的发展具有重要意义。实验设计：本研究以J1胚胎干细胞（Embryonic Stem Cell, ESC）株作为对照组，以稳定转染EWS-OCT4的细胞株与稳定转染OCT4的细胞株作为实验组。所有实验均进行三次重复。