Profiling of THP-1 cells infected with H37Rv (wild-type), ∆E (deletion mutant of PknE), C∆E (complemented ∆E). Homo sapiens

Goal was to determine cellular changes on global macrophage gene expression. Overall design: Transcriptional profiling of THP-1 differentiated macrophages infected with H37Rv, ∆E, C∆E comparing to control uninfected THP-1 macrophages.

本研究旨在解析巨噬细胞（macrophage）全局基因表达的细胞层面改变。实验整体设计：以未感染的THP-1巨噬细胞为对照，对分别经H37Rv、∆E、C∆E菌株感染的分化型THP-1巨噬细胞开展转录组分析。