Interaction of GPVI and FceRI gamma

Glycoprotein VI (GPVI) was identified as a collagen receptor from studies of patients with a GPVI deficiency. GPVI-deficient platelets lack collagen-induced aggregation and the ability to form thrombi on a collagen surface under flow conditions. GPVI complexes with the Fc epsilon R1 receptor gamma chain, with a possible stoichiometry of two GPVI molecules and one FceRI gamma-chain dimer (Jung & Moroi 2008). GPVI binding to FcR gamma is necessary for high affinity GPVI binding to collagen.

从研究GPVI（糖蛋白VI）缺乏症患者的实验中，GPVI被确认为一种胶原蛋白受体。GPVI缺乏的血小板缺乏由胶原蛋白诱导的聚集以及在高流速条件下在胶原蛋白表面形成血栓的能力。GPVI与Fc epsilon R1受体γ链形成复合物，其可能的化学计量比为两个GPVI分子与一个FceRI γ链二聚体（Jung & Moroi 2008）。GPVI与FcR γ的结合对于高亲和力GPVI与胶原蛋白的结合是必要的。