2025_2026_Dynalife_Sozopol_Workshop

This workshop will explore biological information through its dual nature: "digital" and "analog." These distinct modes of information processing in biological systems are deeply interconnected, collectively contributing to the regulation and functioning of living organisms. The "digital" aspect refers to genomic sequences —a linear, discrete coding system in DNA that operates via precise, rule-based codes (e.g., nucleotide sequences encoding proteins). This structure enables robust, error-corrected transmission of genetic information, allowing small, discrete units (genes) to be read, replicated, and passed on with high fidelity. Conversely, "analog" information arises from dynamic, continuous processes, particularly within signal-transduction pathways and cellular interactions. These pathways relay information in a graded manner, modulating responses to environmental stimuli, stress, or internal changes. The workshop seeks to advance understanding of biological information by emphasizing its dual nature and fostering synergy between theoretical and experimental perspectives.

Key questions include:

- How do theoretical models capture the interaction between digital genomic information and analog signal transduction pathways?
- Can a unified framework be developed to account for both types of information processing?
- How do findings in gene regulation, signaling networks, and epigenetics refine existing models of biological information?
- What roles do noise, stochasticity, and robustness play in these processes?

The workshop will highlight the potential of interdisciplinary collaborative research in addressing societal challenges, including AI development and applications, as well as public health, among other areas. These contributions aim to bridge the gap between research and real-world application, inspiring and motivating younger participants to pursue this complex and impactful career path.

__Dates:__ 4-5 September 2025

__Venue:__ Sozopol, Bulgaria, Hotel Villa List

__Scientific Committee:__ Nevena Ilieva, Oreste Piro, Julyan Cartwright

__Local Organizing Committee:__ Nevena Ilieva, Elena Lilkova

本次研讨会将围绕生物信息的双重属性展开深入探讨：「数字」与「模拟」。生物系统中这两种截然不同的信息处理模式深度关联，共同维系生命体的调控与正常运作。
「数字」属性指基因组序列（genomic sequences）：DNA中呈线性排列的离散编码系统，依托精准的规则化编码机制运作，例如核苷酸序列编码蛋白质的过程。该结构可实现具备纠错机制的遗传信息可靠传输，使得离散的小型功能单元——基因（genes）能够以高保真度完成读取、复制与传递。
与之相对，「模拟」信息源自动态连续的生命过程，尤其体现在信号转导通路（signal-transduction pathways）与细胞互作环节中。此类通路以分级梯度的方式传递信息，调节生命体对环境刺激、应激或内部状态变化的应答反应。
本次研讨会旨在通过强调生物信息的双重属性，推动理论与实验研究视角的协同融合，深化学界对生物信息的认知。
核心研讨议题包括：
- 理论模型应如何捕捉数字基因组信息与模拟信号转导通路之间的交互作用？
- 能否构建统一的理论框架，同时涵盖这两类信息处理模式？
- 基因调控、信号网络与表观遗传学（epigenetics）领域的研究发现，将如何优化现有的生物信息模型？
- 噪声、随机性与鲁棒性（robustness）在上述生命过程中扮演何种角色？

本次研讨会还将彰显跨学科合作研究在应对各类社会挑战中的应用潜力，此类挑战涵盖人工智能（AI）的开发与应用、公共卫生等诸多领域。相关研究成果旨在弥合基础科研与实际应用之间的鸿沟，同时激励并引导青年参与者投身这一兼具复杂性与重要影响力的研究方向。

__日期：__ 2025年9月4日至5日
__举办地点：__ 保加利亚索佐波尔，利斯特别墅酒店（Hotel Villa List）
__科学委员会：__ 内韦娜·伊利耶娃（Nevena Ilieva）、奥雷斯特·皮罗（Oreste Piro）、朱利安·卡特赖特（Julyan Cartwright）
__本地组织委员会：__ 内韦娜·伊利耶娃（Nevena Ilieva）、埃琳娜·利尔科娃（Elena Lilkova）