GDSC1

GDSC1 PharmacoSet (PSet) generated by ORCESTRA. Metadata can be found on ORCESTRA at: https://www.orcestra.ca/pset/10.5281/zenodo.5787084 Disclaimer The GDSC1 data have been generated and shared by the Wellcome Trust Sanger Institute as part of the Genomics of Drug Sensitivity in Cancer (GDSC) Programme. The Haibe-Kains Lab has reprocessed and re-annotated the data to maximize overlap with other pharmacogenomic datasets. Data Usage Policy Users have a non-exclusive, non-transferable right to use data files for internal proprietary research and educational purposes, including target, biomarker and drug discovery. Excluded from this licence are use of the data (in whole or any significant part) for resale either alone or in combination with additional data/product offerings, or for provision of commercial services. Please note: The data files are experimental and academic in nature and are not licensed or certified by any regulatory body. Genome Research Limited provides access to data files on an “as is” basis and excludes all warranties of any kind (express or implied). If you are interested in incorporating results or software into a product, or have questions, please contact [e-mail]. Source: https://depmap.sanger.ac.uk/documentation/data-usage-policy/ Sanger's terms and conditions: http://www.cancerrxgene.org/legal Please cite the following when using these data Iorio F, Knijnenburg TA, Vis DJ, Bignell GR, Menden MP, Schubert M, Aben N, Gonçalves E, Barthorpe S, Lightfoot H, Cokelaer T, Greninger P, van Dyk E, Chang H, de Silva H, Heyn H, Deng X, Egan RK, Liu Q, Mironenko T, Mitropoulos X, Richardson L, Wang J, Zhang T, Moran S, Sayols S, Soleimani M, Tamborero D, Lopez-Bigas N, Ross-Macdonald P, Esteller M, Gray NS, Haber DA, Stratton MR, Benes CH, Wessels LFA, Saez-Rodriguez J, McDermott U, Garnett MJ. A Landscape of Pharmacogenomic Interactions in Cancer. Cell. 2016 Jul 28;166(3):740-754. doi: 10.1016/j.cell.2016.06.017. Epub 2016 Jul 7. PMID: 27397505; PMCID: PMC4967469. Yang W, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S, Bindal N, Beare D, Smith JA, Thompson IR, Ramaswamy S, Futreal PA, Haber DA, Stratton MR, Benes C, McDermott U, Garnett MJ. Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res. 2013 Jan;41(Database issue):D955-61. doi: 10.1093/nar/gks1111. Epub 2012 Nov 23. PMID: 23180760; PMCID: PMC3531057. Picco G, Chen ED, Alonso LG, Behan FM, Gonçalves E, Bignell G, Matchan A, Fu B, Banerjee R, Anderson E, Butler A, Benes CH, McDermott U, Dow D, Iorio F, Stronach E, Yang F, Yusa K, Saez-Rodriguez J, Garnett MJ. Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening. Nat Commun. 2019 May 16;10(1):2198. doi: 10.1038/s41467-019-09940-1. PMID: 31097696; PMCID: PMC6522557.

由ORCESTRA生成的GDSC1药物组数据集（PharmacoSet，简称PSet），其元数据可在ORCESTRA平台的以下链接获取：https://www.orcestra.ca/pset/10.5281/zenodo.5787084

免责声明：本GDSC1数据集由威康桑格研究所（Wellcome Trust Sanger Institute）作为《癌症药物敏感性基因组学（Genomics of Drug Sensitivity in Cancer，简称GDSC）计划》的一部分生成并共享。海贝-凯恩实验室（Haibe-Kains Lab）已对该数据集进行重新处理与重新注释，以最大化其与其他药物基因组数据集的重叠度。

数据使用政策：用户享有非排他性、不可转让的使用权，可将数据文件用于内部专有研究与教育用途，包括靶点、生物标志物及药物发现相关工作。本许可协议禁止以下使用行为：将数据（全部或任何重要部分）单独或与其他数据/产品组合后转售，或用于提供商业服务。

请注意：本数据集文件属于实验性与学术性内容，未获得任何监管机构的许可或认证。基因组研究有限公司（Genome Research Limited）按"现状"提供数据集访问服务，并免除所有明示或默示的担保责任。若您有意将本数据集结果或相关软件整合至产品中，或有任何疑问，请联系邮箱[e-mail]。

数据来源：https://depmap.sanger.ac.uk/documentation/data-usage-policy/
桑格研究所条款与条件：http://www.cancerrxgene.org/legal

使用本数据集时，请引用以下文献：
1. Iorio F, Knijnenburg TA, Vis DJ, 等. 癌症中药物基因组相互作用的全景图谱. 细胞（Cell）. 2016年7月28日;166(3):740-754. DOI: 10.1016/j.cell.2016.06.017. 2016年7月7日在线发表. PMID: 27397505; PMCID: PMC4967469.
2. Yang W, Soares J, Greninger P, 等. 癌症药物敏感性基因组学（GDSC）：癌细胞治疗性生物标志物发现资源. 核酸研究（Nucleic Acids Research）. 2013年1月;41(数据库特刊):D955-61. DOI: 10.1093/nar/gks1111. 2012年11月23日在线发表. PMID: 23180760; PMCID: PMC3531057.
3. Picco G, Chen ED, Alonso LG, 等. 通过药理学与CRISPR-Cas9筛选评估基因融合与癌细胞适应性的功能关联. 自然通讯（Nature Communications）. 2019年5月16日;10(1):2198. DOI: 10.1038/s41467-019-09940-1. PMID: 31097696; PMCID: PMC6522557.