UCD Cleft primary palate 4.9 Mb candidate region targeted sequencing

Birds of the congenic inbred chicken line UCD Cleft primary palate (UCD cpp.003) carry an autosomal recessive mutation observed as a lethal developmental defect in affected homozygous mutant progeny. This mutation was mapped to a 4.9 Mb region of chromosome 11, and which is sequenced in this project in several individuals of the UCD cpp.003 line with the aim of assessing variation linked to the mutation, and ultimately determining the causative element.

同源近交鸡系UCD原发性腭裂（UCD cpp.003）的个体携带常染色体隐性突变，受该突变影响的纯合突变子代表现出致死性发育缺陷表型。该突变已被定位至11号染色体的4.9 Mb区域；本项目将对该品系的多个个体进行测序，旨在评估与该突变相关的遗传变异，并最终确定其致病元件。