Unpaired analysis of proteins showing differential expression between baseline and week 8 in <i>n</i> = 39 TB patients.

A total of 60 proteins were differentially expressed using the KS test and 0.01% false discovery rate (q <10−4; for all 116 proteins with q <10−3 see Table S4). The shift in expression is shown as the signed KS-distance, with a positive KS value indicating up-regulation of the protein after 8 weeks of TB therapy. Also shown are the raw p-value and resulting FDR corrected “q-value”. *Swiss Prot is a large protein sequence database widely used for protein resources.通过柯尔莫哥洛夫-斯米尔诺夫（Kolmogorov-Smirnov, KS）检验结合0.01%的错误发现率（false discovery rate, FDR）筛选，共获得60个差异表达蛋白（q < 10^-4；q < 10^-3的全部116个蛋白详见附表S4）。蛋白的表达变化以带符号KS距离（signed KS-distance）呈现，KS值为正代表经过8周结核病（TB）治疗后该蛋白表达上调。本研究同时展示了原始p值以及经FDR校正得到的q值。 *瑞士蛋白序列数据库（Swiss-Prot）是广泛应用于蛋白资源研究的大型蛋白序列数据库。