A long-period and high-stability three-dimensional surface-enhanced Raman scattering hotspot matrix

A novel long-period and high-stability 3D hotspot matrix was constructed with the assistance of glycerol based on our previous study on the dynamic-SERS approach in the water system: it could increase efficient hotspot duration from few seconds to twenty minutes and strongly improve sensitivity and reproducibility for SERS detection.基于我们此前在水体系中针对动态表面增强拉曼散射（dynamic-SERS）方法开展的研究，本研究借助甘油构建了一种新型长周期高稳定性三维热点基底。该基底可将有效热点的持续时长从数秒提升至20分钟，并显著提升SERS检测的灵敏度与重现性。