Cell-extracellular matrix interactions

Cell-extracellular matrix (ECM) interactions play a critical role in regulating a variety of cellular processes in multicellular organisms including motility, shape change, survival, proliferation and differentiation. Cell-ECM contact is mediated by transmembrane cell adhesion receptors, such as integrins, that interact with extracellular matrix proteins as well as a number of cytoplasmic adaptor proteins. Many of these adaptor proteins physically interact with the actin cytoskeleton or function in signal transduction. <br>Several protein complexes interact with the cytoplasmic tail of integrins and function in transducing bi-directional signals between the ECM and intracellular signaling pathways (reviewed in Sepulveda et al., 2005).<br>Early events that are triggered by interactions with ECM, such as formation/turnover of Focal Adhesions, regulation of actin dynamics and protrusion of lamellipodia to promote cellular spreading and motility are modulated by PINCH- ILK- parvin complexes (see Sepulveda et al., 2005). A number of partners of the PINCH-ILK-parvin complex components have been identified that regulate and/or mediate the functions of these complexes (reviewed in Wu, 2004). Interactions with some of these partners modulate cytoskeletal remodeling and cell spreading.

细胞-细胞外基质（ECM）相互作用在调节多细胞生物中的多种细胞过程，包括运动、形态变化、存活、增殖和分化等方面发挥着至关重要的作用。细胞与ECM的接触由跨膜细胞粘附受体介导，例如整合素，它们与细胞外基质蛋白以及众多细胞质适配蛋白相互作用。其中许多适配蛋白与细胞骨架的肌动蛋白相互作用，或在信号转导中发挥作用。数个蛋白质复合物与整合素的细胞质尾部相互作用，并在介导ECM与细胞内信号通路之间的双向信号转导中发挥作用（参见Sepulveda等，2005年的综述）。由ECM相互作用触发的早期事件，如焦点粘附的形成/周转、肌动蛋白动力学的调节以及伪足的伸出以促进细胞扩散和运动，受到PINCH-ILK- parvin复合物（参见Sepulveda等，2005年的综述）的调控。已鉴定出PINCH-ILK-parvin复合物成分的多个合作伙伴，这些合作伙伴调节和/或介导这些复合物的功能（参见Wu，2004年的综述）。与这些合作伙伴的相互作用调节细胞骨架重排和细胞扩散。

搜集汇总

背景与挑战

背景概述

该数据集名为'Cell-extracellular matrix interactions'，ID为R-HSA-446353.3，研究物种为人类（Homo sapiens），评分为5/5。数据集详细描述了细胞与细胞外基质（ECM）的相互作用，包括这些相互作用在细胞运动、形态变化、存活、增殖和分化等过程中的关键作用，以及通过整合素等跨膜细胞粘附受体介导的信号传导机制。