Differential Gene Expression Analysis of Acinetobacter baumannii Clinical isolates treated with different antibiotics : Transcriptomic Approach

The genus Acinetobacter has undergone significant taxonomic modification over the last 30 years. Its most important representative, Acinetobacter baumannii, has emerged as one of the most troublesome pathogens for health care institutions globally. An opportunistic pathogen, A. baumannii has a high incidence among immune-compromised individuals, particularly those who have experienced a prolonged (> 90d) hospital stay. Commonly associated with aquatic environments, it has been shown to colonize the skin as well as being isolated in high numbers from the respiratory and oropharynx secretions of infected individuals.3 In recent years, it has been designated as a red alert human pathogen, generating alarm among the medical fraternity, arising largely from its extensive antibiotic resistance spectrum.This project was done in collaboration with Department of Microbiology, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai , Tamil Nadu India.Other submitters include Monika Ranjan Tatapudi ([e-mail]), Naveena latha J ([e-mail]), AS Smiline Girija ([e-mail])

不动杆菌属（Acinetobacter）在过去30年间经历了重大的分类学修订。该属最重要的代表物种——鲍曼不动杆菌（Acinetobacter baumannii），已成为全球医疗机构面临的最棘手病原菌之一。作为一种机会致病菌，鲍曼不动杆菌在免疫功能受损人群中发病率较高，尤其是那些住院时长超过90天的患者。该菌通常与水生环境相关，已被证实可定植于皮肤，且可在感染者的呼吸道及口咽分泌物中大量分离得到[3]。近年来，由于其广泛的抗生素耐药谱，鲍曼不动杆菌被列为红色警戒人类病原菌，引发了医学界的广泛警惕。本项目与印度泰米尔纳德邦金奈市萨维塔医学与技术科学研究所、萨维塔大学附属萨维塔牙科学院及医院微生物学系合作完成。其他提交者包括莫妮卡·兰詹·塔塔普迪（[e-mail]）、纳维娜·拉塔·J（[e-mail]）以及AS斯米琳·吉里贾（[e-mail]）