Treatment of orbital lymphatic malformation with oral sirolimus: a case report

ABSTRACT It is estimated that lymphatic malformations in children account for 6% of all benign vascular malformations. New medical therapies have been developed for the management of lymphatic orbital disease. The purpose of this article was to describe a clinical case of orbital venolymphatic malformation in a 10-year-old boy, causing proptosis and palpebral edema. The lesion was initially treated with local sclerotherapy. However, the lesion relapsed, and was successfully treated with oral sirolimus. Prospective studies are warranted to determine the appropriate dose and extend the indications of sirolimus in these patients.

摘要
据统计，儿童淋巴管畸形约占所有良性血管畸形的6%。目前已开发出针对眼眶淋巴管疾病的新型诊疗手段。本文旨在报道一例10岁男性患儿的眼眶静脉淋巴管畸形临床病例，该患儿表现为突眼与眼睑水肿。病灶最初采用局部硬化疗法进行治疗，但随后复发，后通过口服西罗莫司（sirolimus）成功实现治愈。未来需开展前瞻性研究，以明确西罗莫司在这类患者中的适宜剂量，并拓展其临床应用指征。