A complement to the theory of biological evolution: individual evolution and genetic mechanism hypothesis

Abstract In this article, by studying some clinical cases of myopia patients and performing the related analyses, we proposed a conjecture for the causes of myopia and its underlying genetic pathway. Based on that, we designed an experiment to prove the hypothesis of individual evolution. Individual evolution refers to the process of individual trait changes caused by certain external environmental factors, which can be inherited to the next generation. The generation (n) of cloned mice will be classified into X (n1, n1…nx) groups, and the daily exercise amount of each group will be defined as Tx (exercise time). Firstly, we will compare the changes in weight and muscle volume among all groups. Subsequently, the first generation of cloned mice will be used to obtain the second generation of cloned mice, and then grouped in the same way. Then, we will evaluate the effects of exercise on gene expression. For the nth generation, the expression levels of individual genes will be determined, and the individual evolution related indexes will be measured. Environmental factors can affect the changes in an individual state, and such alteration can be fed back to the genetic pathways and passed from one generation to the next.

摘要：本研究通过分析近视患者的若干临床病例并开展相关关联分析，针对近视的致病机制及其潜在遗传通路提出相关假说。在此基础上，我们设计了一项实验以验证个体进化假说。个体进化指由特定外部环境因素诱导个体性状发生改变，并可传递至子代的过程。本实验将第n代克隆小鼠划分为X（n₁、n₂…nₓ）组，每组的每日运动量设为Tₓ（以运动时长为指标）。首先，比较各组小鼠的体重与肌肉量变化；随后，以第一代克隆小鼠为亲本繁育第二代克隆小鼠，并按相同方式分组；继而评估运动对基因表达的调控作用。针对第n代小鼠，检测单个基因的表达水平，并测定与个体进化相关的各项指标。环境因素可影响个体状态的改变，此类改变可反馈至遗传通路并跨代传递。