Detection of genetic variations associated with phenotypic changes in dengue virus driven by serially passaging in cell line

Dengue virus serotype 1 was isolated from patient's plasma. Then, dengue virus was serially passaged in cell culture.

从患者血浆中分离得到登革病毒1型血清型（Dengue virus serotype 1），随后将该登革病毒在细胞培养体系中进行连续传代培养。