Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients

Respiratory failure (RF) is the main cause of hospital admission in HIV/AIDS patients. This study assessed comorbidities and laboratory parameters in HIV/AIDS inpatients with RF (N = 58) in relation to those without RF (N = 36). Tuberculosis showed a huge relative risk and platelet counts were slightly higher in HIV/AIDS inpatients with RF. A flow cytometry assay for reactive oxygen species (ROS) showed lower levels in platelets of these patients in relation to the healthy subjects. However, when stimulated with adrenaline, ROS levels increased in platelets and platelet-derived microparticles of HIV/AIDS inpatients, which may increase the risk of RF during HIV and tuberculosis (HIV-TB) coinfection.

呼吸衰竭（Respiratory Failure，RF）是艾滋病病毒/获得性免疫缺陷综合征（HIV/AIDS）患者住院的主要原因。本研究针对58例合并呼吸衰竭的艾滋病病毒/获得性免疫缺陷综合征住院患者（N=58）与36例未合并呼吸衰竭的同类患者，对比分析了其合并症与实验室检测指标。肺结核（Tuberculosis，TB）在合并呼吸衰竭的患者中呈现出极高的相对风险，且此类患者的血小板计数略高于未合并者。采用流式细胞术（Flow Cytometry）检测活性氧（Reactive Oxygen Species，ROS）的结果显示，相较于健康受试者，此类患者的血小板内活性氧水平更低。然而，当以肾上腺素刺激时，此类艾滋病病毒/获得性免疫缺陷综合征住院患者的血小板及血小板源性微粒（Platelet-Derived Microparticles）内的活性氧水平会升高，这可能会增加艾滋病病毒与肺结核合并感染（HIV-TB）患者发生呼吸衰竭的风险。