Interviews on Trials Transparency at Pubic Research Institutions in the UK, 2020-2021

Ensuring the reporting of clinical research is essential to informed evidence generation in medicine. The UK has seen politicians, funders, and other stakeholder focus on transparency which has translated to pressure on sponsors to ensure greater transparency of their research. This study aimed to collect the institutional perspective to transparency issues in clinical research. Past research on publication bias has largely focused on investigators, however the institutions that house these investigators create the environments which can promote more open and transparent research, including ensuring the reporting of results. In this study, I conducted structured interviews with professionals working in research governance, trial management, and administrative leadership positions to understand how their practice and policies have changed in recent years. This includes understanding motivations for change, how best practices are developed and shared, and barriers to improvement. This collection includes 12 interviews with 14 participants across 11 research institutions. All participants agreed to the sharing on anonymised transcripts on the ReShare service during the informed consent process.

确保临床研究报告的规范性对于医学领域循证证据的生成至关重要。英国政界人士、资助方及其他利益相关者已将焦点投向透明度问题，这转化为对研究申办方的压力，要求其提高研究透明度。本研究旨在收集机构层面关于临床研究透明度问题的观点。以往关于发表偏倚（publication bias）的研究多聚焦于研究者，但容纳这些研究者的机构所营造的环境，能够推动更开放、透明的研究实践，包括确保研究结果的报告。本研究通过对研究治理、试验管理及行政领导岗位的专业人员进行结构化访谈，探究其近年来在实践与政策方面的变化。这包括了解变革的动因、最佳实践的形成与共享机制，以及改进过程中的障碍。本数据集包含对11家研究机构14名参与者的12次访谈记录。所有参与者在知情同意过程中均同意将匿名访谈转录本（transcript）通过ReShare服务共享。