Butyric Acid-Engineered Escherichia coli Nissle 1917 Mitigates Burn-Induced Intestinal Dysfunction and Enhances Cutaneous Wound Repair

该数据集支持利用合成生物学工程细菌治疗烧伤和烫伤的研究。通过对大肠杆菌Nissle 1917的修饰，我们构建了能够高效生产丁酸盐的工程菌株EcN-BA1。数据集包括：工程菌株构建：基因编辑和体外丁酸盐产量数据。安全性评估：抗生素敏感性、肠道定植和体内清除率数据。This dataset supports research on treating burns and scalds with synthetic biology-engineered bacteria. By modifying Escherichia coli Nissle 1917, we constructed an engineered strain EcN-BA1 capable of efficiently producing butyrate. The dataset includes the following content: 1. Construction of the engineered strain: data on gene editing and in vitro butyrate production; 2. Safety assessment: data on antibiotic susceptibility, intestinal colonization, and in vivo clearance rate.