Dermatomyositis skin transcriptomic signature. Dermatomyositis skin transcriptomic signature

Dermatomyositis is a cutaneous and muscular auto-immune condition associated with specific autoantibodies. MDA5 antibody-associated DM has higher mortality. We demonstrate here for the first time using skin microarray analysis that MDA5+ DM is associated with a greater type I interferon skin signature than MDA5- DM, mainly involving the IFN- κ member produced by skin keratinocytes Overall design: We planned to identify genes associated with dermatomyositis as compared to healthy donnors on skin samples. Dermatomyositis sample allow also to investigate gene expression associated with their serological status.

皮肌炎（Dermatomyositis）是一类累及皮肤与肌肉的自身免疫性疾病，与特异性自身抗体密切相关。伴MDA5抗体的皮肌炎死亡率更高。本研究首次通过皮肤微阵列分析证实，与MDA5阴性（MDA5-）皮肌炎相比，MDA5阳性（MDA5+）皮肌炎的皮肤I型干扰素特征更为显著，其主要涉及皮肤角质形成细胞分泌的IFN-κ亚型。
实验设计：本研究旨在通过皮肤样本，筛选出与健康对照者相比与皮肌炎相关的基因；皮肌炎样本同时亦可用于探究与其血清学状态相关的基因表达情况。