Aerosol uptake and biomarker of exposure - contrast

This dataset was generated in an in vivo OECD TG 413 90-days nose-only inhalation study where Sprague Dawley rats were exposed of either aerosols of the mentholated version of the tobacco heating system 2.2 (THS2.2M) or smoke of 2 two mentholated reference cigarettes (MRC(LM) and MRC(HM)) in comparison with 3R4F cigarette smoke. The study contains additional test groups that were examined following a systems toxicology approach (please refer to the study page for more detail on the study design). Biomarkers of exposure, including markers of exposure in blood, plasma and urine were measured. This dataset contains the statistics resulting from the comparison of treatment and control groups.

本数据集源自一项符合经合组织（OECD）试验指南413（TG 413）的体内90天鼻吸入暴露试验。试验中，斯普拉格-道利大鼠（Sprague Dawley rats）分别暴露于烟草加热系统2.2薄荷味版本（THS2.2M）的气溶胶，以及2种薄荷味参比卷烟（MRC(LM)与MRC(HM)）的烟气，并以3R4F卷烟烟气作为对照。本试验设置了额外的受试组，采用系统毒理学方法开展相关检测（试验设计的详细信息请参阅试验页面）。研究人员对暴露生物标志物进行了检测，包括血液、血浆及尿液中的暴露标志物。本数据集包含受试组与对照组比较后得到的统计数据。