Identification of genetic markers of resistance to macrolide class antibiotics in Mannheimia haemolytica. Mannheimia haemolytica

Mannheimia haemolytica is a major contributor to bovine respiratory disease, which causes substantial economic losses to the beef industry each year, and there is an urgent need for more rapid and accurate diagnostic tests to provide evidence for treatment decisions and support antimicrobial stewardship. In this study, we identified genetic markers of resistance in M. haemolytica to macrolide class antibiotics, the most commonly used antimicrobials for the prevention of bovine respiratory disease.

溶血性曼氏杆菌（Mannheimia haemolytica）是引发牛呼吸道疾病（bovine respiratory disease）的主要致病菌，每年给肉牛产业造成巨额经济损失，因此亟需研发更快速精准的诊断检测方法，为治疗决策提供科学依据并支撑抗菌药物管理工作。本研究鉴定出了溶血性曼氏杆菌对大环内酯类抗生素（macrolide class antibiotics）的耐药遗传标记，而该类抗生素是预防牛呼吸道疾病最常用的抗菌药物。