Multicomponent Radical Processes: Synthesis of Substituted Piperidinones

Three and four-component radical and radical−organometallic processes have been developed that provide a simple access to 2,3-disubstituted piperidinones. Reasonable yield and high stereoselectivities were achieved in a number of cases with three C−C bonds and one C−N bond and up to three stereogenic centers generated in one pot from readily available reagents.

现已开发出三组分及四组分自由基与自由基-金属有机反应体系，可为2,3-二取代哌啶酮的合成提供简便路径。在诸多反应案例中，该体系以易得的试剂为起始原料，通过一锅法构建三根碳-碳键与一根碳-氮键，最多可生成三个手性中心，同时实现了可观的反应收率与优异的立体选择性。