Opn3 dependent changes in transcriptome of adipose and liver tissue in the postnatal mouse

Opn3 knock out mice show transcriptional changes in these tissues that are indicative of deregulation of mitochondrial function, extracellular matrix and growth factor signaling, fatty acid oxidation and uptake defects. Intercapular adipose tissue, inguinal white adipose tissue and liver samples were collected from postnatal day 17, Opn3 wild-type and knock-out mice at ZT1.

Opn3敲除（Opn3 knock out）小鼠在上述组织中出现的转录变化，提示线粒体功能、细胞外基质、生长因子信号通路、脂肪酸氧化及摄取过程存在调控异常。本研究于授时因子时间1（Zeitgeber Time 1，ZT1），从出生后第17天的Opn3野生型（wild-type）与敲除小鼠体内采集了肩胛间脂肪组织（Intercapular adipose tissue）、腹股沟白色脂肪组织（inguinal white adipose tissue）及肝脏样本。