Molecular basis for vulnerability to mitochondrial and oxidative stress in an insulinoma cell line

CONCLUSIONS/SIGNIFICANCE: The molecular profile presented here will enable identification of individual genes or gene clusters that shape vulnerability to mitochondrial dysfunction and thus represent potential therapeutic targets for diabetes and neurodegenerative diseases. In addition, the newly identified CRI-G1-RS cell line represents a new experimental model for investigating how endogenous antioxidants affect glucose sensing and insulin release by pancreatic ß cells.结论与意义：本研究呈现的分子谱可用于鉴定决定线粒体功能障碍易感性的单个基因或基因簇，进而可作为糖尿病与神经退行性疾病的潜在治疗靶点。此外，新鉴定出的CRI-G1-RS细胞系为探究内源性抗氧化剂如何影响胰腺β细胞的葡萄糖感知与胰岛素分泌提供了全新的实验模型。