A dual functions of autism-related chromatin remodeler CHD8 in developmental and adult neurogenesis

The loss-of-function mutations in the chromatin remodeler CHD8, a high-risk factor in autism spectrum disorder (ASD), lead to severe developmental delay, however, the underlying mechanisms remains elusive. Here, we use transcriptome and genomic occupancy reveal that CHD8 regulates chromatin accessibility and activates neurogenesis-related genes for cortical neurogenesis. Overall design: 9 samples

染色质重塑因子（chromatin remodeler）CHD8是自闭症谱系障碍（autism spectrum disorder, ASD）的高危风险因子，其功能丧失突变可引发严重的发育迟缓，但其潜在的分子机制仍尚未阐明。本研究借助转录组学与基因组结合占据分析，揭示CHD8能够调控染色质开放性，并激活与神经发生相关的基因以参与皮层神经发生。实验整体设计：共包含9个样本。